ECH1 Polyclonal Antibody

Background:
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans, 5-cis-dienoyl-CoA to 2-trans, 4-trans-dienoyl-CoA, indicating that it is a delta3, 5-delta2, 4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.

Research Area: Cancer, Cardiovascular, Metabolism, Signal transduction, Tags & Cell Markers

Synonyms:
4)-dienoyl-CoA isomerase, 5)-Delta(2, Delta(3 5) Delta(2 4) dienoyl CoA isomerase, Delta(3 5) Delta(2 4) dienoyl CoA isomerase mitochondrial, Delta(3, Delta3 5 delta2 4 dienoyl CoA isomerase, Dienoyl CoA isomerase, ECH 1, Ech1, ECH1, Enoyl Coenzyme A hydratase 1, Enoyl Coenzyme A hydratase 1 peroxisomal, HPXEL, mitochondrial, MS1034, Peroxisomal enoyl CoA hydratase 1, Peroxisomal enoyl coenzyme A hydratase like protein

Immunogen: Fusion protein of human ECH1

Swissprot: Q13011
Gene Accession: BC011792

Calculated MW: 36 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.