EDARADD Polyclonal Antibody

Background:
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Research Area: Epigenetics and Nuclear Signaling, Developmental biology, Signal transduction

Synonyms:
Cr, Crinkled homolog, ectodysplasia A receptor associated death domain, Ectodysplasin-A receptor-associated adapter protein, ED3, EDA3, EDAD, EDAR associated death domain, EDAR-associated death domain protein, EDARADD, Protein crinkled homolog

Immunogen: Full length fusion protein

Swissprot: Q8WWZ3
Gene Accession: BC128082

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:35-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.