EDEM1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60705
Background:
Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein is a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p.
Alternative Name:
ER degradation-enhancing alpha-mannosidase-like protein 1, EDEM1, EDEM, KIAA0212
Application Dilution: WB: 1:500~1:1000
Specificity: EDEM1 polyclonal antibody detects endogenous levels of EDEM1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human EDEM1
MW: ~ 74 kDa
Swis Prot.: Q92611
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein is a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p.
Alternative Name:
ER degradation-enhancing alpha-mannosidase-like protein 1, EDEM1, EDEM, KIAA0212
Application Dilution: WB: 1:500~1:1000
Specificity: EDEM1 polyclonal antibody detects endogenous levels of EDEM1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human EDEM1
MW: ~ 74 kDa
Swis Prot.: Q92611
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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