EDN1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6036
Background:
The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3, also known as ET-1, ET-2, and ET-3. Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action. The two receptor subtypes responsible for inducing vasoconstriction and vasodilation, ETA and ETB, have different receptor affinities for ET-1, ET-2, and ET-3. Of the three isopeptides, ET-2 has the most potent vasoconstrictor activity (1). Biologically active ETs are proteolytically generated from a larger precursor, the big-endothelin, by action of the endothelin-converting enzyme (ECE) family. ET-1 is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells.
Alternative Name:
Big endothelin 1, Big endothelin-1, EDN 1, EDN1, EDN1 protein, EDN1, Endothelin1, ET 1, ET-1, ET1, OTTHUMP00000039245, PPET 1, PPET1, Preproendothelin 1, Preproendothelin-1, Preproendothelin1,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: EDN1 polyclonal antibody detects endogenous levels of EDN1 protein.
Immunogen:
Recombinant full length Human EDN1.
MW: ~ 23 kDa
Swis Prot.: P05305
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3, also known as ET-1, ET-2, and ET-3. Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action. The two receptor subtypes responsible for inducing vasoconstriction and vasodilation, ETA and ETB, have different receptor affinities for ET-1, ET-2, and ET-3. Of the three isopeptides, ET-2 has the most potent vasoconstrictor activity (1). Biologically active ETs are proteolytically generated from a larger precursor, the big-endothelin, by action of the endothelin-converting enzyme (ECE) family. ET-1 is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells.
Alternative Name:
Big endothelin 1, Big endothelin-1, EDN 1, EDN1, EDN1 protein, EDN1, Endothelin1, ET 1, ET-1, ET1, OTTHUMP00000039245, PPET 1, PPET1, Preproendothelin 1, Preproendothelin-1, Preproendothelin1,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: EDN1 polyclonal antibody detects endogenous levels of EDN1 protein.
Immunogen:
Recombinant full length Human EDN1.
MW: ~ 23 kDa
Swis Prot.: P05305
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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