EDN3 polyclonal (C-term), anti-human

Background:
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Other Names:
Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3

Target/Specificity:
This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.

Antigen Region:
168-197

Antigen Type: Synthetic Peptide

Gene Name: EDN3
Gene ID: 1908
Primary Accession: P14138
NCBI Accession: NP_000105.1;NP_996915.1;NP_996916.1;NP_996917.1
Other Accession: Q03229;NP_000105
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.