EEF1E1 Polyclonal Antibody

Background:
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.

Research Area: Cancer, Cell Biology

Synonyms:
AIMP 3, AIMP3, Aminoacyl tRNA synthetase complex interacting multifunctional protein 3, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3, ARS interacting multifunctional protein 3, EEF1E1, Elongation factor p18, Eukaryotic translation elongation factor 1 epsilon 1, Eukaryotic translation elongation factor 1 epsilon-1, Homolog of rat elongation factor p18, MCA3, Multisynthase complex auxiliary component p18, Multisynthetase complex auxiliary component p18, p18, p18 component of aminoacyl tRNA synthetase complex

Immunogen: Full length fusion protein

Swissprot: O43324
Gene Accession: BC005291

Calculated MW: 20 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.8 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.