EEF2K Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP8162b
Background:
Eukaryotic elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2, thereby inhibiting peptide-chain elongation. eEF2k, which is Ca2+ and calmodulin dependent, can be activated by PKA in response to stress-induced elevation of cAMP levels. eEF2k expression is also modulated by a wide range of stimuli that promote cell growth and protein synthesis. Phosphorylation of eEF2k by p90RSK and p70 S6 kinase at Ser366 or by SAPK4/p38d at Ser359, inactivates eEF2k, which facilitates the dephosphorylation of eEF2, and thus promotes translation.
Other Names:
Eukaryotic elongation factor 2 kinase, eEF-2 kinase, eEF-2K, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, EEF2K
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8162b was selected from the C-term region of human EEF2K. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EEF2K
Gene ID: 29904
Primary Accession: O00418
Other Accession: NP_037434
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Eukaryotic elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2, thereby inhibiting peptide-chain elongation. eEF2k, which is Ca2+ and calmodulin dependent, can be activated by PKA in response to stress-induced elevation of cAMP levels. eEF2k expression is also modulated by a wide range of stimuli that promote cell growth and protein synthesis. Phosphorylation of eEF2k by p90RSK and p70 S6 kinase at Ser366 or by SAPK4/p38d at Ser359, inactivates eEF2k, which facilitates the dephosphorylation of eEF2, and thus promotes translation.
Other Names:
Eukaryotic elongation factor 2 kinase, eEF-2 kinase, eEF-2K, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, EEF2K
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8162b was selected from the C-term region of human EEF2K. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EEF2K
Gene ID: 29904
Primary Accession: O00418
Other Accession: NP_037434
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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