EFCAB4A polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254379
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
Alternate Names: EFCAB4A, EF-hand calcium binding domain 4A, Calcium release-activated calcium channel regulator 2, CRACR2B
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_775855
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human EFCAB4A.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
EFCAB4A, also known as Calcium release-activated calcium channel regulator 2B, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation, but the detailed function is still under investigation. It is likely to play a similar role as the related protein EFCAB4B, which acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration.
Alternate Names: EFCAB4A, EF-hand calcium binding domain 4A, Calcium release-activated calcium channel regulator 2, CRACR2B
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_775855
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human EFCAB4A.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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