EFCAB4B polyclonal, anti-human, mouse
€484.00
In stock
SKU
254380
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
Alternate Names: EFCAB4B, EF-hand calcium binding domain 4B, Calcium release-activated calcium channel regulator 2, CRACR2A
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_116069
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human EFCAB4B.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
Alternate Names: EFCAB4B, EF-hand calcium binding domain 4B, Calcium release-activated calcium channel regulator 2, CRACR2A
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_116069
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human EFCAB4B.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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