EFCAB4B polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP17969a
Catalog Number: AC-AP17969a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB38227
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB38227
Applications: WB
Datasheet
Request Information
Background:
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Other Names:
EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, Calcium release-activated channel regulator 2A, CRACR2A, EFCAB4B
Target/Specificity:
This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.
Antigen Region:
48-74
Antigen Type: Synthetic Peptide
Gene Name: CRACR2A
Gene ID: 84766
Primary Accession: Q9BSW2
NCBI Accession: NP_001138430.1;NP_116069.1
Other Accession: NP_001138430.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Other Names:
EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, Calcium release-activated channel regulator 2A, CRACR2A, EFCAB4B
Target/Specificity:
This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.
Antigen Region:
48-74
Antigen Type: Synthetic Peptide
Gene Name: CRACR2A
Gene ID: 84766
Primary Accession: Q9BSW2
NCBI Accession: NP_001138430.1;NP_116069.1
Other Accession: NP_001138430.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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