EFNA5 antibody (clone 1F12), anti-human
€435.00
In stock
SKU
AC-AT1861a
Catalog Number: AC-AT1861a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT1861a">Request Information
Background:
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Other Names:
Ephrin-A5, AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7, EFNA5, EPLG7, LERK7
Antigen Type:
Recombinant Protein
Gene Name: EFNA5
Gene ID: 1946
NCBI Accession: NP_001953.1
Primary Accession: P52803
Other Accession: NM_001962
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Other Names:
Ephrin-A5, AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7, EFNA5, EPLG7, LERK7
Antigen Type:
Recombinant Protein
Gene Name: EFNA5
Gene ID: 1946
NCBI Accession: NP_001953.1
Primary Accession: P52803
Other Accession: NM_001962
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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