EFNB1 Polyclonal Antibody

Background:
Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.

Research Area: Cell Biology, Cardiovascular, Developmental Biology, Neuroscience, Signal Transduction

Synonyms:
CFND, CFNS, Craniofrontonasal syndrome (craniofrontonasal dysplasia), EFL 3, EFL-3, EFL3, EFNB1, EFNB1, Elk L, ELK ligand, ELK-L, Eph related receptor tyrosine kinase ligand 2, EPH-related receptor tyrosine kinase ligand 2, Ephrin-B1, EPLG2, LERK 2, LERK-2, LERK2, Ligand of eph related kinase 2, MGC8782

Immunogen: Synthetic peptide of human EFNB1

Swissprot: P98172
Gene Accession: NP004420

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.