EGF Receptor (clone 3F12-1H7-A10), anti-human

Background:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Synonyms: ERBB, ERBB1, HER1, mENA, NISBD2, PIG61

Cellular Location: Cell membrane Endoplasmic reticulum membrane Endosome Endosome membrane Golgi apparatus membrane Nucleus membrane Nucleus Secreted Single-pass type I membrane protein

Immunogen:
Purified recombinant human EGFR protein fragments expressed in E.coli.

Gene Symbol: EGF Receptor

Gene ID: 1956

Swiss prot: P00533

Calculated MW: 175kDa

Recommended dilution:
WB 1:1000, ICC 1:200, IHC 1:800

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.