EGFR (clone AT6E3), anti-human

Decription:
Epidermal growth factor receptor (EGFR) is a 170 kDa membrane protein first identified as a binding partner of EGF. Also, EGFR phosphorylated itself (autophosphorylation) in response to EGF treatment. The overexpression of EGFR in various epithelial tumors was widely reported and it has been substantiated that deregulation of EGFR itself and its signaling pathways an important role in human cancers.

Synonyms: ERBB, ERBB1, Epidermal growth factor receptor, HER1, PIG61, epidermal growth factor receptor, Urogastrone, Proto-oncogene c-ErbB-1, Oncogene ERBB, Cell proliferation inducing protein 61, Cell growth inhibiting protein 40, Avian erythroblastic leukemia viral (verbb) oncogene homolog

Clone: AT6E3. Anti-human EGFR mAb, clone AT6E3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EGFR protein.

Isotype: Mouse IgG2b kappa

Immunogen: Recombinant human EGFR (424-605aa) purified from E. coli

Reactivity: human

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide

Applications: ELISA, WB

Working Dilution: Optimal dilution should be performed by user.

NCBI Nr.: NP_005219

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

References:
Cohen S, (1964) Nat Cancer Inst Monogr, 13: 13-27.
Toyoda H, et al. (1995) J Biol Chem, 270: 7495-500.
Carpenter G, et al. (1978) Nature,276: 409-10.