EGFR (L858R Mutant Specific) (clone MD27R), anti-human

Description:
Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, which occurs in exon 21 and short in-frame deletions in exon 19. A common lesion in exon 19 is the deletion of E746-A750, although other variants occur. IHC-based EGFR E746-A750del specific antibody is designed to detect deletion of E746-A750 in exon 19. Deletion in exon 19 is associated with response of non-small cell lung carcinoma (NSCLC) to gefitinib or erlotinib monotherapy.

Localization: membrane

Dilution: Prediluted

Positive Control: lung ca. L858R mutant specific

Epitope Retrieval: EDTA pH8.0

NOTE : For Research Use Only - RUO