EGFR (phospho-Y845) polyclonal, anti-human

Background:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Synonyms: ERBB, ERBB1, HER1, NISBD2, PIG61, mENA

Cellular Location: Cell membrane Endoplasmic reticulum membrane Endosome Endosome membrane Golgi apparatus membrane Nucleus membrane Nucleus Secreted Single-pass type I membrane protein

Immunogen:
A phospho specific peptide corresponding to residues surrounding Y845 of human EGFR

Gene Symbol: Phospho-EGFR-Y845

Gene ID: 1956

Swiss prot: P00533

Calculated MW: 134kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.