EGFR Polyclonal Antibody

Background:
EGFR,also named as ERBB1,is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12,encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression,including cell proliferation,apoptosis,angiogenesis,and metastatic spread. Mutations in this gene are associated with lung cancer.

Research Area: Cancer, Signal Transduction

Synonyms:
Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, EGF R, EGFR, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor, erb-b2 receptor tyrosine kinase 1, ERBB, ERBB1, Errp, HER1, mENA, NISBD2, SA7, wa2, Wa5

Immunogen: Recombinant Human Epidermal growth factor receptor protein

Swissprot: P00533

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 0.57 mg/mL
Dilution: IHC 1:100-1:200 IF 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.