EGR2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Early growth response protein 2, also called EGR2 or E3 SUMO-protein ligase EGR2, is a protein that in humans is encoded by the EGR2 gene. This gene is mapped to 10q21.3. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D(CMT1D), Charcot-Marie-Tooth disease type 4E(CMT4E), and with Dejerine-Sottas syndrome(DSS). E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.

Description:
Rabbit IgG polyclonal antibody for E3 SUMO-protein ligase EGR2 (EGR2) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
AT591 antibody, CMT1D antibody, CMT4E antibody, DKFZp686J1957 antibody, E3 SUMO-protein ligase EGR2 antibody, Early growth response 2 antibody, Early growth response protein 2 antibody, EGR-2 antibody, egr2 antibody, EGR2_HUMAN antibody, FLJ14547 antibody, KROX 20 Drosophila homolog antibody, Krox 20 homolog Drosophila antibody, KROX-20, Drosophila, homolog(early growth response-2) antibody, KROX20 antibody, Krox20 protein antibody, Zinc finger protein Krox-20 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human EGR2(153-168aa TMSQTQPDLDHLYSPP), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse.
Predicted to work with: rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.