eIF2α (phospho-S51) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4787
Background:
eIF2α, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2α controls the rate of tRNA translation. When eIF2α is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2α is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
Alternative Name:
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A, EIF2S1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-eIF2α (S51) polyclonal antibody detects endogenous levels of eIF2αprotein only when phosphorylated at Ser51.
Immunogen:
Synthetic phosphopeptide derived from human eIF2α around the phosphorylation site of Serine 51.
MW: ~ 38 kDa
Swis Prot.: P05198
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
eIF2α, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2α controls the rate of tRNA translation. When eIF2α is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2α is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
Alternative Name:
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A, EIF2S1
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-eIF2α (S51) polyclonal antibody detects endogenous levels of eIF2αprotein only when phosphorylated at Ser51.
Immunogen:
Synthetic phosphopeptide derived from human eIF2α around the phosphorylation site of Serine 51.
MW: ~ 38 kDa
Swis Prot.: P05198
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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