EIF2AK1 polyclonal, anti-human

Quantity: 100 µg

Background:
EIF2AK1(Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1), also called HRI, is an enzyme that in humans is encoded by the EIF2AK1 gene. Hartz(2010) mapped the EIF2AK1 gene to chromosome 7p22.1 based on an alignment of the EIF2AK1 sequence with the genomic sequence. Chen and London(1995) reviewed the activation and control of rat and rabbit Hri. Hri functions as a dimer, and its activation involves autophosphorylation, which requires an invariant lysine in kinase domain II. Using cDNA arrays and Northern blot analysis, Hwang et al.(2000) found that HRI was downregulated in the majority of ovarian cancers examined compared with normal ovarian tissues.

Description:
Rabbit IgG polyclonal antibody for Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) detection. Tested with WB, ICC in Human.

Synonyms:
E2AK1_HUMAN antibody, EC 2.7.11.1 antibody, Eif2ak1 antibody, Eukaryotic translation initiation factor 2 alpha kinase 1 antibody, Eukaryotic translation initiation factor 2-alpha kinase 1 antibody, HCR antibody, Heme controlled repressor antibody, Heme regulated eukaryotic initiation factor eIF 2 alpha kinase antibody, Heme regulated inhibitor antibody, Heme regulated initiation factor 2 alpha kinase antibody, Heme regulated repressor antibody, Heme sensitive initiation factor 2a kinase antibody, Heme-controlled repressor antibody, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase antibody, Heme-regulated inhibitor antibody, Hemin sensitive initiation factor 2 alpha kinase antibody, Hemin-sensitive initiation factor 2-alpha kinase antibody, HRI antibody, KIAA1369 antibody, PRO1362 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human EIF2AK1(466-483aa CTDILQKNTDWTNRNGKR).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.