EIF2AK3 Polyclonal Antibody

Background:
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
EIF2AK3, PEK, PERK, WRS

Immunogen: Recombinant protein of human EIF2AK3

Swissprot: Q9NZJ5
Gene ID: 9451

Calculated MW: 125 kDa
Observed MW: 160 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.