EIF2C3 AGO3 monoclonal, anti-human, mouse, rat

Description: Anti-EIF2C3 AGO3 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Protein Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4..

Other Names: Protein argonaute-3 {ECO:0000255|HAMAP-Rule:MF_03032}, Argonaute3 {ECO:0000255|HAMAP-Rule:MF_03032}, hAgo3, 3.1.26.n2, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF-2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, AGO3, EIF2C3

Clone Name(s):
Clone: GGF-1

Subcellular Localization: Cytoplasm, P-body.

Gene ID: 192669

Immunogen: A synthesized peptide derived from human EIF2C3

Calculated MW: 97360

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.