EIF2S1 antibody (clone 3H12-C11), anti-human
€435.00
In stock
SKU
AC-AT1875a
Catalog Number: AC-AT1875a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
Request Information AC-AT1875a">Request Information
Background:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Other Names:
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2S1, EIF2A
Antigen Type:
Recombinant Protein
Gene Name: EIF2S1 (HGNC:3265)
Gene ID: 1965
NCBI Accession: NP_004085.1
Primary Accession: P05198
Other Accession: BC002513
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Other Names:
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2S1, EIF2A
Antigen Type:
Recombinant Protein
Gene Name: EIF2S1 (HGNC:3265)
Gene ID: 1965
NCBI Accession: NP_004085.1
Primary Accession: P05198
Other Accession: BC002513
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
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