EIF2S1 polyclonal, anti-human, mouse, rat

Background:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).

Synonyms: EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A

Cellular Location: Cytoplasmic granule

Immunogen:
Recombinant Protein of human EIF2S1

Gene Symbol: EIF2S1

Gene ID: 1965

Swiss prot: P05198

Calculated MW: 36kDa

Recommended dilution:
WB 1:500-1000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.