EIF3H Polyclonal Antibody

Background:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
eIF-3-gamma, eIF3 gamma, eIF3 p40, eIF3 p40 subunit, eIF3h, EIF3H, EIF3S3, Eukaryotic translation initiation factor 3 subunit 3, Eukaryotic translation initiation factor 3 subunit H, MGC102958

Immunogen: Recombinant protein of human EIF3H

Swissprot: O15372
Gene Accession: BC000386

Calculated MW: 40 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-16359/sc-50355