EIF4A1 Monoclonal Antibody

Background:
EIF4A1 is an ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
ATP-dependent RNA helicase eIF4A-1, DDX2, DDX2A, eIF 4A I, eIF-4A-I, EIF4A, eIF4A I, eIF4A-I, EIF4A1, Eukaryotic initiation factor 4A-I, Eukaryotic initiation factor 4AI, eukaryotic translation initiation factor 4A, isoform 1, Eukaryotic translation initiation factor 4A1, IF4A1

Immunogen: Synthetic Peptide

Swissprot: P60842
Observed MW: 48 kDa

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-1:3000, IHC 1:50-1:300, IF 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-14211/sc-50354