eIF4B (phospho-Ser422) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
AP0084
Background:
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.It is phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1.phosphorylation enhances the affinity of EIF4B for the EIF3 complex
Alternative Name:
Eukaryotic translation initiation factor 4B, eIF-4B, EIF4B
Application Dilution: WB: 1:500~1:1000
Specificity: p-eIF4B(Ser422) polyclonal antibody detects endogenous levels of eIF4B protein only when phosphorylated at Ser422.
Immunogen:
Synthetic phosphopeptide derived from human eIF4B around the phosphorylation site of Serine 422.
MW: ~ 80 kDa
Swis Prot.: P23588
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.It is phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1.phosphorylation enhances the affinity of EIF4B for the EIF3 complex
Alternative Name:
Eukaryotic translation initiation factor 4B, eIF-4B, EIF4B
Application Dilution: WB: 1:500~1:1000
Specificity: p-eIF4B(Ser422) polyclonal antibody detects endogenous levels of eIF4B protein only when phosphorylated at Ser422.
Immunogen:
Synthetic phosphopeptide derived from human eIF4B around the phosphorylation site of Serine 422.
MW: ~ 80 kDa
Swis Prot.: P23588
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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