eIF4E [clone EP280], anti-human

Description: Eukaryotic initiation factor 4E (elF4E), a 25-kDa cap binding protein, delivers cellular mRNAs to the elF4F translation initiation complex by binding the 5'-cap structure of these mRNAs. Studies suggested that increased expression and activity of elF4E might be one of the key effects on oncogene expression, resulting in neoplastic transformation. elF4E is overexpressed in many types of cancers, including carcinoma of the breast, colon, bladder, cervix, lung, and squamous cell carcinoma of the head and neck. Increased expression of elF4E has been associated with tumor progression in breast cancer, prostate cancer, and acute myeloid leukemia (AML). High expression of elF4E is associated with adverse tumor characteristics and predicts poor breast cancer-specific survival.Localization: nucleus, cytoplasmDilution: 50-200Positive Control: breast caHIER: citrate pH6.0 or EDTA pH8.0Status: RUO