EIF4E (S1232) polyclonal, anti-human

Bio Backgrounds:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

Other Names:
Eukaryotic translation initiation factor 4 gamma 1, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, p220, EIF4G1, EIF4F, EIF4G, EIF4GI

Target/Specificity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Gene Name:
EIF4G1
Gene ID:
1981
NCBI Accession:
NP_004944.3;NP_886553.3;NP_937884.1;NP_937885.1
Primary Accession: Q04637

Format: affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.