EIF4E (S209) polyclonal, anti-human, mouse, rat

Bio Backgrounds:
All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).

Other Names:
Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F

Target/Specificity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Gene Name:
EIF4E (HGNC:3287)
Gene ID:
1977
NCBI Accession:
NP_001124150.1;NP_001124151.1;NP_001959.1
Primary Accession: P06730

Format: affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.