EIF4EBP1 Polyclonal Antibody

Background:
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4EBP1

Immunogen: A synthetic peptide of human EIF4EBP1 (NP_004086.1).

Swissprot: Q13541
Gene ID: 1978

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.