EIF4G1 Polyclonal Antibody

Background:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
DKFZp686A1451, eIF 4 gamma 1, eIF 4G 1, eIF 4G1, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, EIF4 gamma, EIF4F, EIF4G, EIF4G1, EIF4GI, Eukaryotic translation initiation factor 4 gamma 1, IF4G1, p220

Immunogen: Synthetic peptide of human EIF4G1

Swissprot: Q04637
Gene Accession: NP_004944

Calculated MW: 175 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-9602/sc-9601/sc-11373