CLK2 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP69155
Catalog Number: AC-AP51185
Size: 100 µl
Host: Rabbit
Applications: WB, IP, IHC-P, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IP, IHC-P, E
Datasheet
Request Information
Background:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Other Names:
CLK2; Dual specificity protein kinase CLK2; CDC-like kinase 2
Antigen Type: synthetic peptide
Antigen Type: CLK2
Gene ID: 1196
Primary Accession: P49760
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Other Names:
CLK2; Dual specificity protein kinase CLK2; CDC-like kinase 2
Antigen Type: synthetic peptide
Antigen Type: CLK2
Gene ID: 1196
Primary Accession: P49760
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