ELA2 antibody (clone 300000), anti-human
€435.00
In stock
SKU
AC-AT1887a
Catalog Number: AC-AT1887a
Size: 50 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT1887a">Request Information
Size: 50 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT1887a">Request Information
Background:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Other Names:
Neutrophil elastase, Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2
Antigen Type:
Recombinant Protein
Gene Name: ELANE
Gene ID: 1991
NCBI Accession: NP_001963.1
Primary Accession: P08246
Other Accession: NM_001972
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Other Names:
Neutrophil elastase, Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2
Antigen Type:
Recombinant Protein
Gene Name: ELANE
Gene ID: 1991
NCBI Accession: NP_001963.1
Primary Accession: P08246
Other Accession: NM_001972
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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