ELAC2 Polyclonal Antibody

Background:
The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
ELAC2, COXPD17, ELC2, HPC2

Immunogen: Recombinant fusion protein of human ELAC2 (NP_776065.1).

Swissprot: Q9BQ52
Gene ID: 60528

Calculated MW: 50 kDa/56 kDa/87 kDa/92 kDa
Observed MW: 105 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.