ELAVL1 polyclonal, anti-human, mouse, rat

Background:
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

Alternative Name:
HuR, ELAVL1, HUR, ELAV (embryonic lethal abnormal vision Drosophila) like 1, ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R), ELAV like 1, ELAV like RNA binding protein 1, ELAV-like protein 1, ELAV1, ELAV1, Elavl1, Embryonic lethal abnormal vision drosophila homolog like 1, Hu Antigen R, Hu-antigen R, Hua, HuR, MelG,

Application Dilution:
WB:1:500-1:2,000
IHC:1:100-1:500
FC:1:50-1:100
IP:1:10-1:50

Specificity: ELAVL1 polyclonal antibody detects endogenous levels of ELAVL1 protein.

Immunogen:
Recombinant protein

Swiss-Prot: Q15717(Human) P70372(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.