ELF3 Polyclonal Antibody

Background:
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
E74 like factor 3, E74 like factor 3 ets domain transcription factor, E74 like factor 3 ets domain transcription factor epithelial specific, E74 like factor 3 ETS domain transcription factor serine box epithelial specific, E74-like factor 3, Elf3, ELF3, Epithelial restricted with serine box , Epithelial-restricted with serine box, Epithelium restricted Ets protein ESX, Epithelium specific Ets factor 1, Epithelium specific Ets transcription factor 1, Epithelium-restricted Ets protein ESX, Epithelium-specific Ets transcription factor 1, EPR 1, EPR1, ERT, ESE-1, ESX, Ets domain transcription factor serine box, Ets domain transcription factor serine box epithelial specific, Ets transcription factor, ETS-related transcription factor Elf-3, jen, MGC139318

Immunogen: Fusion protein of human ELF3

Swissprot: P78545
Gene Accession: BC003569

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.68 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.