ELOC Polyclonal Antibody

Background:
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
Elongin C, Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C), RNA Polymerase II Transcription Factor SIII Subunit C, Transcription Elongation Factor B Polypeptide 1, Transcription Elongation Factor B Subunit 1, Elongin 15 KDa Subunit, SIII P15.

Immunogen: Fusion protein of human ELOC

Swissprot: Q15369
Gene Accession: BC013809

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.