ELP2 Polyclonal Antibody

Background:
One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate.

Research Area: Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
AU023723, Elongation protein 2 homolog (S. cerevisiae), Elongator acetyltransferase complex subunit 2, Elongator complex protein 2, elongator protein 2, ELP2, ELP2, Epl2, FLJ10879, SHINC 2, SHINC-2, SHINC2, signal transducer and activator of transcription 3 interacting protein 1, signal transducer and activator of transcription interacting protein 1, STAT3 interacting protein 1, Stat3 interacting protein, STAT3-interacting protein 1, STATIP 1, STATIP1, STATIP1 protein, StIP, StIP1

Immunogen: Recombinant protein of human ELP2

Swissprot: Q6IA86
Gene Accession: BC032553

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-33152/sc-69007/sc-69010