EMI1 (Early Mitotic Inhibitor-1) (clone EMI1/1176 ), anti-human

Background:
It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

Other Names:
F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5

Gene Name: FBXO5 (HGNC:13584)
Gene ID: 26271
Primary Accession: Q9UKT4
Other Accession: 26271, 520506