ENC1 antibody (clone 3B1), anti-human
€435.00
In stock
SKU
AC-AT1905a
Catalog Number: AC-AT1905a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
Request Information AC-AT1905a">Request Information
Background:
DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.
Other Names:
Ectoderm-neural cortex protein 1, ENC-1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein, ENC1, KLHL37, NRPB, PIG10
Antigen Type:
Recombinant Protein
Gene Name: ENC1
Gene ID: 8507
NCBI Accession: NP_001243503.1;NP_001243504.1;NP_001243505.1;NP_003624.1
Primary Accession: O14682
Other Accession: NM_003633
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.
Other Names:
Ectoderm-neural cortex protein 1, ENC-1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein, ENC1, KLHL37, NRPB, PIG10
Antigen Type:
Recombinant Protein
Gene Name: ENC1
Gene ID: 8507
NCBI Accession: NP_001243503.1;NP_001243504.1;NP_001243505.1;NP_003624.1
Primary Accession: O14682
Other Accession: NM_003633
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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