Endoglin / CD105 (clone ENG/1327), anti-human
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In stock
SKU
AC-AH13192
Catalog Number: AC-AH13192
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: ENG/1327
Applications: WB, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: ENG/1327
Applications: WB, IF, FC
Datasheet
Request Information
Background:
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Other Names:
CD105; END; Endoglin; Eng; HHT1; S-endoglin
Antigen Type:
Recombinant protein
Gene Name: ENG
Gene ID: 2022
Primary Accession: P17813
Other Accession: 76753
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Other Names:
CD105; END; Endoglin; Eng; HHT1; S-endoglin
Antigen Type:
Recombinant protein
Gene Name: ENG
Gene ID: 2022
Primary Accession: P17813
Other Accession: 76753
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