Endostatin polyclonal, anti-human, mouse, rat

Protein Family: CAM Ligands

Pathway and Disease: Cell Growth and Death

Description:
Collagen alpha-1(XVIII) chain (endostatin) plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Defects in endostatin are a cause of Knobloch syndrome (KNO). KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.

Alternate Names: Endostatin, Collagen alpha-1(XVIII) chain, COL18A1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P39060

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human endostatin.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.