Endothelin 1 Peptide
€843.00
In stock
SKU
350161
Protein Family: Hormones
Pathway and Disease: Signaling Molecules and Interaction
Alternate Names: Endothelin-1; preproendothelin-1; PPET1; ET-1; EDN1
Accession No.: P05305
Description:
Endothelin-1 (ET-1) is the predominant isoform of the endothelins, a family of endothelium-derived vasoconstrictor peptides. Endothelin-1 is expressed as a 212-aa precursor (preproendothelin-1) that is sequentially cleaved into 2 chains: Endothelin-1 (21 aa) and Big Endothelin-1 (38 aa). Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE), chymases and non-ECE metalloproteases. ET-1 exerts various biological effects, including vasoconstriction and the stimulation of cell proliferation in tissues via ET receptors A and B.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 2491.95 g/mol
Sequence:
Human: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Cys1-Cys15, Cys3-Cys11) or H-CSCSSLMDKECVYFCHLDIIW-OH (Cys1-Cys15, Cys3-Cys11)
Composition:
C109H159N25O32S5
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Pathway and Disease: Signaling Molecules and Interaction
Alternate Names: Endothelin-1; preproendothelin-1; PPET1; ET-1; EDN1
Accession No.: P05305
Description:
Endothelin-1 (ET-1) is the predominant isoform of the endothelins, a family of endothelium-derived vasoconstrictor peptides. Endothelin-1 is expressed as a 212-aa precursor (preproendothelin-1) that is sequentially cleaved into 2 chains: Endothelin-1 (21 aa) and Big Endothelin-1 (38 aa). Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE), chymases and non-ECE metalloproteases. ET-1 exerts various biological effects, including vasoconstriction and the stimulation of cell proliferation in tissues via ET receptors A and B.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 2491.95 g/mol
Sequence:
Human: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Cys1-Cys15, Cys3-Cys11) or H-CSCSSLMDKECVYFCHLDIIW-OH (Cys1-Cys15, Cys3-Cys11)
Composition:
C109H159N25O32S5
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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