Endothelin-1 polyclonal, anti-human, mouse, rat, Other, bovine, pig

Protein Family: Hormones

Pathway and Disease: Endocrine System, Signaling Molecules and Interaction

Description:
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin-1 (ET-1) is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Endothelin-1 is expressed as a 212-aa precursor (preproendothelin-1) that is sequentially cleaved into 2 chains: Endothelin-1 (21 aa) and Big Endothelin-1 (38 aa). This antibody recognizes Big Endothelin-1 and precursor forms.

Alternate Names: Endothelin-1, preproendothelin-1, PPET1, ET-1, EDN1, Big Endothelin-1, Big ET-1

Application Notes: Product Cat. No. 250640 recognizes Big Endothelin-1 and precursor forms but not the 21-aa Endothelin-1. E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P05305

Antigen: KLH-conjugated synthetic peptide corresponding to a region within human Big Endothelin-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] DeNiro M et al. 2013. PLoS ONE. 8(3): :e59021. PMID# 23533599.
[2] Hayashi K et al. 2012. Animal Reproduction Science. 134, 150-157. PMID# 22921266.
[3] Hammond T et al. 2014. Neuron. 81(3): 588-602. PMID# 24507193.
[4] Fradet A et al. 2013. PLoS ONE. 8(9):e75092. PMID# 24069383.