Enigma/PDLIM7/LMP1 [clone D10], anti-human, mouse, rat

Description: Enigma, or PDLIM7 (PDZ and LIM domain 7) or LMP1 (LIM mineralization protein), is a 457 amino acid protein that localizes to both the cytoplasm and the cytoskeleton. Expressed ubiquitously with highest expression in skeletal muscle, spleen, lung and fetal liver, Enigma is thought to function as a scaffold on which protein assembly can occur. Enigma contains three LIM zinc-binding domains and one PDZ domain through which it may also act as an adaptor, linking various proteins to actin filaments found in skeletal muscle and non-muscle tissues. Additionally, Enigma is directly involved in the two mechanisms of bone formation, namely direct bone formation (embryonic flat bones mandible and cranium) and endochondral bone formation (embryonic long bone development), and may play a role in bone fracture repair. Localization: cytoplasm, membraneDilution: 50-250Positive Control: infiltrating ductal breast carcinoma tissue; HeLa cellsHIER: citrate pH6.0 or EDTA pH8.0Status: RUO