ENPP7 Polyclonal Antibody

Background:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7(E-NPP 7) also known asalkaline sphingomyelin phosphodiesterase(Alk-SMase) orintestinal alkaline sphingomyelinaseis anenzymethat in humans is encoded by theENPP7gene. Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA. Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
ALK SMase, Alk-SMase, Alkaline sphingomyelin phosphodiesterase, E-NPP 7, Ectonucleotide pyrophosphatase/phosphodiesterase 7, Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, ENPP7, ENPP7, Intestinal alkaline sphingomyelinase, NPP-7

Immunogen: Synthetic peptide of human ENPP7

Swissprot: Q6UWV6
Gene Accession: NP_848638

Calculated MW: 52 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-49352/sc-134737