Eotaxin polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
Eotaxin, also known as CCL11(Chemokine(C-C motif) ligand 11), a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxinis a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1(CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.

Description:
Rabbit IgG polyclonal antibody for Eotaxin (CCL11) detection. Tested with WB in Mouse, Rat.

Synonyms:
C-C motif chemokine 11 antibody, CCL 11 antibody, CCL11 antibody, CCL11_HUMAN antibody, chemokine(C-C motif) ligand 11 antibody, Chemokine C C motif ligand 11 antibody, Chemokine CC Motif Ligand 11 antibody, Chemokine ligand 11 antibody, Eosinophil Chemotactic Protein antibody, Eotaxin antibody, eotaxin-1 antibody, MGC22554 antibody, SCYA 11 antibody, SCYA11 antibody, Small inducible cytokine A11 antibody, Small inducible cytokine subfamily A(Cys Cys) member 11 antibody, small inducible cytokine subfamily A(Cys-Cys), member 11(eotaxin) antibody, Small inducible cytokine subfamily A member 11 antibody, Small-inducible cytokine A11 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Eotaxin(73-93aa CADPKKKWVQDATKHLDQKLQ), identical to the related rat sequence.A synthetic peptide corresponding to a sequence at the C-terminus of mouse Eotaxin(73-93aa CADPKKKWVQDATKHLDQKLQ), identical to the related rat sequence.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.