Ep-CAM (clone G8.8), anti-mouse
€564.00
In stock
SKU
ARP-21-5077
Catalog Number: 21-5077
Size: 100 µg
Isotype: Rat IgG2a
Size: 100 µg
Isotype: Rat IgG2a
Background:
Ep-CAM is a 40 kD glycoprotein and can be detected at the basolateral membrane of the majority of epithelial tissues, where it is intriCately linked with the cadherin-Catenin complex and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. This antigen functions as a homotypic calcium-independent cell adhesion molecule. Of particular interest, Ep-CAM appears to be overexpressed by the majority of Human epithelial carcinomas, including colorectal, breast, prostate, head and neck, and hepatic carcinomas. The antigen is being used as a target for immunotherapy of Human carcinomas. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation.
Clone: G8.8
Isotype: Rat IgG2a
Source: G8.8 is a Rat monoclonal IgG2a antibody derived by fusion of spleen lymphocytes from Rats repeatedly immunized with a glycoconjugates isloted from TE-71 BALB/c Mouse derived medullary thymic epithelial cells and Rat X63-Ag8.653 myeloma cells.
Reactivity: mouse
Specificity: The G8.8 antibody reacts with CD326/Ep-CAM (Epithelial Cell Adhesion Molecule), also known as gp-40 in the Mouse. Ep-CAM is a 40-42-kDa cell-surface glycoprotein expressed on thymic epithelial cells, thymic dendritic cells, immature thymocytes, a small subset of peripheral T lymphocytes, intestinal epithelium, kidney-collecting tubule epithelium, Keratinocytes, Langerhans cells, as well as lymph node and splenic dendrititc cells.
Form: Each vial contains 100ul of purified antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (frozen), Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Ep-CAM is a 40 kD glycoprotein and can be detected at the basolateral membrane of the majority of epithelial tissues, where it is intriCately linked with the cadherin-Catenin complex and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. This antigen functions as a homotypic calcium-independent cell adhesion molecule. Of particular interest, Ep-CAM appears to be overexpressed by the majority of Human epithelial carcinomas, including colorectal, breast, prostate, head and neck, and hepatic carcinomas. The antigen is being used as a target for immunotherapy of Human carcinomas. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation.
Clone: G8.8
Isotype: Rat IgG2a
Source: G8.8 is a Rat monoclonal IgG2a antibody derived by fusion of spleen lymphocytes from Rats repeatedly immunized with a glycoconjugates isloted from TE-71 BALB/c Mouse derived medullary thymic epithelial cells and Rat X63-Ag8.653 myeloma cells.
Reactivity: mouse
Specificity: The G8.8 antibody reacts with CD326/Ep-CAM (Epithelial Cell Adhesion Molecule), also known as gp-40 in the Mouse. Ep-CAM is a 40-42-kDa cell-surface glycoprotein expressed on thymic epithelial cells, thymic dendritic cells, immature thymocytes, a small subset of peripheral T lymphocytes, intestinal epithelium, kidney-collecting tubule epithelium, Keratinocytes, Langerhans cells, as well as lymph node and splenic dendrititc cells.
Form: Each vial contains 100ul of purified antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (frozen), Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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