Epac1 polyclonal, anti-human, mouse

Background:
3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus.

Alternative Name:
EPAC 1, cAMP-GEFI, RAPGEF3, CGEF1, EPAC, EPAC1, bcm910, CAMP GEFI, cAMP regulated guanine nucleotide exchange factor I, CAMPGEFI, CGEF 1, CGEF1, EPA1, Epac 1, EPAC, EPAC1, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, MGC21410, RAP guanine nucleotide exchange factor, Rap guanine nucleotide exchange factor (GEF) 3, RAP guanine nucleotide exchange factor 3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, RAPGEF3,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200
IP:1:10-1:50
ICC/IF:1:10-1:50

Specificity: Epac1 polyclonal antibody detects endogenous levels of Epac1 protein.

Immunogen:
Recombinant protein

Swiss-Prot: O95398(Human) Q8VCC8(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.